Fibronectin is an extracellular matrix protein found in most animal tissues. It is primarily responsible for supporting cell adhesion and migration. Defined as key term in Cell Biology 6.14.4 Fibronectins connect cells to collagenous matrices
a fiber-forming glycoprotein composed of two disulfide-bonded subunits of 220,000 daltons each, that promotes cell adhesion.
Natural glycoprotein, the organizing protein in the dermal matrix, which reinforces dermis cohesion. Known cellular strengthener and cellular regenerator that provides firming, toning, protection and moisture to the skin.
adhesive glycoprotein found within the ECM that mediates extracellular matrix assembly and cell attachment to the ECM.
proteins recognized by integrins to interact with collagen
An extracellular multiadhesive protein that binds to other matrix components, fibrin, and cell-surface receptors of the integrin family. It functions to attach cells to the extracellular matrix and is important in wound healing. ( Figure 22-22)
A component of the structural material that surrounds cells (the extracellular matrix). Although important in normal conditions, it becomes a barrier to regrowing axons.
Fibronectin is a high-molecular-weight glycoprotein containing about 5% carbohydrate that binds to receptor proteins that span the cell's membrane, called integrins. In addition to integrins, they also bind extracellular matrix components such as collagen, fibrin and heparin.