Definitions for "Down-regulation"
the process of reducing or suppressing a response to a stimulus; specifically reduction in a cellular response to a molecule (as insulin) due to a decrease in the number of receptors on the cell surface
Suppression of the natural secretion of gonadotropins by using GnRh analogues.
Reduction of the FSh and LH secretion from the pituitary gland by a GnRH agonist or antagonist