The observation that the amount of disease increases as the dose or level of exposure increases.
The relationship between the dose of a substance (such as a drug) and the response of the organism to the substance.
A quantitative relationship between the amount of chemical given to (or taken in) by organisms in a group and the measured effect of the chemical in the organisms, as determined by some type of toxicity test. In a dose-response graph, the amount of chemical is shown on the x-axis.
The relationship between the dose of some agent (such as a drug), or the extent of exposure, and a physiological response. A dose-response effect means that as the dose increases, so does the effect.
A relationship between (1) the dose, often based on an "administered dose" (i.e., exposure) rather than absorbed dose, and (2) the extent of toxic injury produced by that chemical. The response can increase with greater doses and can be expressed either as the severity of injury or proportion of exposed subjects affected.
Association between dose and the incidence of a defined biological effect in an exposed population. emission: Release of a substance from a source, including discharges to the wider environment.
Relationship between the dose of a toxic chemical and the incidence of an adverse effect. This is a fundamental law of toxicology expressed as, "The dose makes the poison." For any poison, there exists a threshold dose below which adverse effects do not occur.
As the amount of exposure to a risk factor increases, the rate of the effect of exposure increases.
Correlation between the amount of exposure to an agent or toxic chemical and the resulting effect on the body.
The relationship between (1) the dose, actually based on "administration dose" (i.e. exposure) rather than actual absorbed dose, and (2) the extent of therapeutic or toxic effect produced by the xenobiotic.
is a fundamental and pervasive concept in toxicology. Dose is the major determinant of toxicity. An understanding of this relationship is essential for an understanding of toxic materials.
Specifically, the relationship between alcohol consumption and a range of positive and negative consequences for the individual and society, including physical illnesses, accidents, violence and mortality.
the relationship between the amount of exposure (dose) and the resulting changes in body function or health (response).
a phenomenon by which increased doses of a drug lead to increased effects, such that the response to a drug is directly related to the dose administered.
The relationship between exposure level and the incidence of adverse effects.
the relationship between the dose of a vaccine and an immune or physiologic response. In vaccine research, a dose-response effect means that as the dose of the vaccine increases, so does the level of the immune response (antibodies and CTL activity).
A relationship in which change in amount, intensity, or duration of exposure is associated with a change-either an increase or decrease-in risk of a specified outcome.
Association between dose and the incidence of a defined biological effect in an exposed population RT concentration-response relationship, response
The relationship between a quantified exposure (dose) and the proportion of subjects demonstrating specific biologically significant changes in incidence and/or in degree of change (response).
The relationship between a quantified exposure (dose), and the proportion of subjects demonstrating specific, biological changes (response). This definition archived 9/30/03
The quantitative relationship between the amount of exposure to a substance and the extent of toxic injury or disease produced.
The Dose-response relationship describes the change in effect on an organism caused by differing levels of exposure (or doses) to a substance. This may apply to individuals (eg: a small amount has no observable effect, a large amount is fatal), or to populations (eg: how many people are affected at different levels of exposure).