A high-density array of DNA molecules used for parallel hybridization analyses.
A small glass or plastic square onto which thousands of single-stranded DNA sequences are fixed. Hybridization of cell-derived RNA or DNA to the target sequences can be performed. (See DNA hybridization.) DNA hybridization • A process by which DNAs from two species are mixed and heated so that interspecific double helixes are formed.
These chips are also referred to as DNA arrays, or microarrays. Approx. 10,000 cDNAs can be spotted onto a microscope slide and subsequently be hybridised with a double-labelled probe. See also: DNA, DNA array, DNA microarray
a proprietary technique for analyzing drinking water using cutting-edge DNA chip technology. More accurate, faster and cheaper than current quality control techniques, the DNA chip offers consumers even more effective water quality control.
DNA chip technology provides efficient access to genetic information using miniaturized, high-density arrays of oligonucleotide probes. A set of oligonucleotides is defined, synthesized, immobilized on silica wafers or chips to construct a high-density array; each probe having a predefined position in the array. Labeled (fluorescence) nucleic acids from the analyzed sample are hybridized on the array, and hybridization intensities are detected by a scanner that reports quantitative assessment of RNA level in the sample for each gene represented in the array.
a microchip that holds DNA probes that form half of the DNA double helix and can recognize DNA from samples being tested
a checkerboard of squares of micrometer size carrying a short fragment of a gene
a collection of DNA spots immobilized on a substrate, such as glass or silicon chip, which can be used to genotype multiple regions of a genome by checking whether or not it binds with sample DNA
a fingernail-sized device containing thousands of probes that, by detecting the presence or absence of specific gene sequences, can literally paint a genetic picture of living cells
a grid of hundreds to hundreds of thousands of individual matching tests mass produced on silicon wafers the size of a dime
A part of the microarray technology scientists use in gene sequencing to understand how the thousands of genes in a genome interact simultaneously.
Small slides with a number of DNA probes attached in a defined order. DNA chips are needed for expression analysis, for the analysis of DNA mutations or polymorphisms.
A microarray of oligonucleotides or cDNA clones fixed on a surface. They are commonly used to test for sequence variation in a known gene, or to profile gene expression in an mRNA preparation.
See microarray. Drosophila melanogaster | A fruit fly that is often used as a model organism for genetics research.
DNA microarrays which, with the appropriate computerised software allow rapid, automated high throughput DNA sequencing and mutation detection.
