The systematic creation of large numbers of small molecules in "libraries" that can be screened in vitro for potential as cancer drugs.
Rapid synthesis of large organized collections of compounds called libraries.
The use of chemical methods to generate all possible combinations of chemicals starting with a subset of compounds. The building blocks may be peptides, nucleic acids or small molecules. The libraries of compounds formed by this methodology are used to probe for new pharmaceutical reagents.
A collection of chemical and computational technologies for synthesizing, simulating and testing molecules to create a 'library' of many different compounds, which can be used to improve the activity of a drug or decrease side effects and reduce the development time and costs for pharmaceutical products.
A robotic system methodically synthesising large numbers of compounds, each having a composition slightly different from the previous one.
Doing many chemical experiments in many reaction vessels at the same time. In this way, a large number of products with a different chemical composition are made in a very efficient manner.
A technique for systematically assembling molecular building blocks in many combinations to create thousands of diverse compounds.
Automated technology that allows chemists to synthesize small quantities of different compounds sharing a similar chemical structure. Often used to synthesis compounds for high-throughput screening of drug candidates.
The random assembly of various chemical units into large so-called "libraries" of new synthetic compounds.
Preparation of collections of compounds by joining molecular building blocks in different combinations. Also known as combichem.
Combinatorial Chemistry - Is used to synthesize large number of chemical compounds by combining sets of building blocks. Each newly synthesized compound's composition is slightly different from the previous one. A traditional chemist can synthesize 100-200 compounds per year. A combinatorial robotic system can produce in a year thousands or millions compounds which can be tested for potential drug candidates in a high-throughput screening process.
using a combinatorial process to prepare sets of compounds from sets of building blocks.
A method for generating large numbers of new substances rapidly by combining specific molecular building blocks in a variety of ways.
the generation of large collections, or "libraries," of molecules by synthesizing all possible combinations of a set of smaller chemical structures. Usually for automated testing (see High throughput screening).
a product discovery technique that uses robotics and parallel chemical reactions to generate and screen as many as several million molecules with similar structures in order to find chemical molecules with desired properties.
testing a large number of related compounds (as a mixture?) to find a compound that is active.
A method for assembling and manipulating molecular and chemical building blocks to create new compounds.
A relatively new approach to drug discovery, it is the act of creating a library of randomly generated molecules to be used in a screen in hopes of finding a molecular configuration that will bind to a specific target (receptor). Once a lead (ligand) is found it can be used to identify a configuration that could be used to create new drugs. These small-molecule libraries can be tagged with a Europium label. The AcroWellâ„¢ plate can be used to detect the bound ligands with a robotic detector; any unbound labels can be washed away.
Combinatorial chemistry involves the rapid synthesis or the computer simulation of a large number of different but structurally related molecules.
