A condition where scar tissue develops in the liver - to the extent where such scarring becomes extensive and permanent. Cirrhosis interferes with the normal functioning of the liver.
a disease of the liver in which the normal lobular structure is replaced by fibrosis and regenerating nodules.
Liver disease characterized by replacement of functioning liver cells by scar tissue.
a condition in the liver that results in scarring of the tissue making it hard for the liver to function properly.
Scarring of the liver tissue, usually as the result of hepatitis. Scarring of liver tissue renders the tissue useless in liver function, and can reduce the function of or restrict blood flow to surrounding liver tissue.
the result of chronic liver disease, where the liver is scarred and no longer functions properly. This causes many complications, including build up of fluid in the abdomen, bleeding disorders, increased pressure in the blood vessels and brain function disorders.
a liver disorder in which the parenchymal cells are destroyed and replaced by connective tissue
Inflammatory disease of the liver characterized by scarring and shrinkage.
A disease of the liver in which normal, healthy tissue is replaced with nonfunctioning tissue and healthy, functioning liver cells are lost; usually occurs when there is a lack of adequate nutrition, an infection or damage caused by alcohol abuse.
An abnormal liver condition where the liver is irreversibly scarred. There are many causes of cirrhosis, such as longstanding alcohol abuse and viral hepatitis B and C. Cirrhosis is confirmed by liver biopsy.
A chronic disease in which normal liver tissue eventually hardens and dies.
a chronic disease of the liver characterized by nodular regeneration of hepatocytes and diffuse fibrosis. It is caused by parenchymal necrosis followed by nodular proliferation of the surviving hepatocytes. The regenerating nodules and accompanying fibrosis interfere with blood flow through the liver and result in portal hypertension, hepatic insufficiency, jaundice and ascites. Cirrhosis is a more severe, irreversible process of liver inflammation, necrosis, and regeneration. In hepatitis C, cirrhosis occurs as a late stage sequela of chronic infection, and may take 20-30 years to develop.
Chronic scarring of the liver, leading to loss of normal liver function.
Progressive scarring and contraction of the liver which eventually disturbs the function of the liver. Causes of cirrhosis included chronic forms of hepatitis B and hepatitis C.
Liver disease characterized by destruction of normal architecture and formation of fibrous nodule. In advanced stages fluid may form in the abdomen and jaundice (increase in bile pigment) may develop.
pathologically-defined disease characterized by diffuse, irreversible fibrosis of the liver surrounding regenerative nodules.
Fibrosis and scarring of the liver which can be caused by a number of diseases. A unique form of cirrhosis occurs in approximately one percent of individuals with CF when thick secretions block the liver's bile ducts.
a chronic disease of the liver causing loss of function of liver cells and decreased blood flow through the liver.
the most advanced stage of liver scarring.
Occurs when liver cells are destroyed by disease, poison, drugs, alcohol etc and are replaced by scar tissue. Scarring interferes with blood flow through the liver, causing more cell death and further scarring. The liver becomes smaller and hard. This can result in the liver being unable to function properly, medically referred to as decompensation.
A liver disorder characterized by the degeneration of hepatocytes and their replacement by fibrous connective tissue.
Pathological dysfunctional state of the liver (hardening of the liver)extensive scarring in the liver along with irregular nodules of regenerating liver tissue. A result of chronic hepatitis, CPH or CAH.
a form of liver disease in which scar tissue stiffens blood vessels, impairing its function; can be caused by drinking too much alcohol, poor nutrition, or infections (especially by hepatitis viruses)
End-stage liver disease caused by hepatitis, alcoholism, or an obstruction of bile flow. Cirrhosis can cause jaundice, gastrointestinal problems, edema, liver failure, and death.
An inflammation of the liver that can increase the risk of certain kinds of gallstones.
a chronic disease interfering with the normal functioning of the liver; the major cause is chronic alcoholism
A group of chronic liver diseases characterized by a certain change in liver tissue structure.
Disfiguration of normal liver structure by increase in fibrous tissue and the formation of small irregular masses that is caused by any of various chronic conditions affecting the liver (long term alcohol abuse or hepatitis)
The most advanced form of liver disease, characterized by extensive scarring that stiffens blood vessels and distorts the internal structure of the liver, severely impairing its function. Although alcoholic cirrhosis often is progressive and fatal, it may stabilize with abstinence.
A disease of the liver in which scar tissue replaces normal, healthy tissue, blocking the flow of blood through the organ and preventing it from working as it should.
1. Any diffuse fibrosis which destroys the normal lobular architecture of the liver with destruction and regeneration of hepatic parenchymal cells. 2. Interstitial inflammation of any tissue or organ.
A chronic liver condition characterized by the growth of fibrous scar tissue, liver cell damage and regeneration, and distortion of liver structure. Cirrhosis can lead to failure of the liver to perform some of its critically important functions such as filtering out drugs and toxins, including alcohol, from the blood.
A serious, often irreversible, and frequently deadly disease of the liver. Usually caused by chronic heavy drinking.
A slowly progressing disease in which healthy liver tissue is replaced with scar tissue, eventually preventing the liver from functioning properly. The scar tissue blocks the flow of blood through the liver and slows the processing of nutrients, hormones, drugs and naturally produced toxins. It also slows the production of proteins and other substances made by the liver.
Permanent liver damage with scarring and other changes.
A condition where damaged normal tissue is replaced with fibrous tissue (similar to scar tissue).
scarring of the liver that cannot be healed. Many chronic liver diseases end in cirrhosis.
a condition in which scar tissue develops on the liver - to the extent where such scarring becomes extensive and is usually permanent. It interferes with the normal functioning of the liver.
Liver disease characterized by diffuse scarring and abnormal regrowth of liver tissue.
A condition where scar rissue develops in the lever - to the extent where such scaring becomes extensive and permanent. Cirrhosis interferes with the normal functioning of the liver.
chronic disease of the liver sometimes caused by alcohol abuse
a chronic disease of the liver in which the liver becomes scarred irreversibly.
progressive disease of the liver characterized by diffuse damage to the hepatic cells; often ultimately resulting in hepatic failure
A disease that affects the liver. Scar tissue replaces normal healthy tissue, stopping the liver from working properly. It has several causes, but alcoholism is one of the most common. Cirrhosis of the liver usually appears after more than ten years of heavy drinking.
Disease of the liver in which the normal architecture is permanently altered and liver function is impaired. Alcohol and hepatitis viruses are important causes but there are many others.
A condition which results from long term liver damage (whether by infection, alcohol, drugs or certain inflammatory diseases) and describes a situation in which the liver becomes scarred and functions poorly. If the damage persists the liver goes on to fail, in which case transplantation is the only option.
a chronic disease that causes the liver to degenerate until it can no longer effectively remove toxic substances from the blood
A condition in which permanent scarring of the liver is present. At this point, permanent damage has occurred which limits the overall function of the liver. The best therapy is identification of the cause of the inflammation and scarring and its correction. As cirrhosis progresses to end-stage liver disease, a liver transplant may be required.
degenerative change of an organ caused by poisons, bacteria or other agents resulting in overgrowth of fibrous tissue
Progressive disease of the liver, characterized by liver cell damage, scarring of the liver, and abnormal liver architecture and function.
A chronic liver disease that is caused by alcohol abuse, toxins, nutritional deficiency, or infection. A main symptom of cirrhosis is portal hypertension.
A diseased condition in which healthy liver tissue becomes replaced by fibrous tissue similar to a scar.
a long term disease of the liver in which the liver becomes covered with fiber-like tissue.
A condition in which the liver does not function normally due to scarring. Healthly liver cells are replaced with non-functioning scar tissue. Alcohol accounts for approximately 50% of all cases.
A disease characterised by the buildup of scar tissue and nodules in the liver that interfere with its function.
chronic liver condition caused by scar tissue and cell damage, which makes it hard for the liver to remove poisons (toxins) like alcohol and drugs from the blood. These toxins build up in the blood and may affect brain function.
a chronic problem makes it hard for the liver to remove toxins (poisonous substances) from the body. Alcohol, medications, and other substances may build up in the bloodstream and cause problems. Cirrhosis is a result of scarring and damage from other diseases, such as biliary atresia and alcoholism.
An abnormal liver condition characterized by irreversible scarring of the liver. Alcohol and viral hepatitis B and C are among the many causes of cirrhosis.
Scarring of the liver that can result in the loss of liver cells and impaired liver function.
a condition in which the liver becomes scarred, fibrous and filled with fat, thus reducing its ability to function. Causes include infection (e.g., hepatitis) and excessive alcohol consumption.
A chronic scarring of the liver that can result in hepatic failure, jaundice and death.
The last stage of scarring of a liver before it stops working.Any disease process that can lead to long-term damage to the liver can lead to cirrhosis. Many patients who develop cirrhosis eventually require a liver transplant.
The end stage of chronic liver disease from any cause. The liver is scarred and its function significantly impaired.
Degeneration of tissue in an organ resulting in fibrosis, with nodule and scar formation. Cirrhosis of the liver interferes with the liver's metabolism of nutrients, detoxification of the blood, bile production, and other normal functions. Its damage is irreversible. The most prevalent form of cirrhosis of the liver, portal cirrhosis, appears most often in middle-aged males with a history of chronic alcoholism and is caused in part by protein deficiency, a type of malnutrition common in alcoholics. Reference: L3
Extensive and, usually, permanent scarring of the liver. Cirrhosis interferes with the normal functioning of the liver.
A chronic degenerative disease of the liver characterized by extensive scarring and hardening. It is most often associated with advanced liver disease.
condition in which hardened scar tissue replaces normal liver tissue and impairs the ability of the liver to function
A serious liver condition characterized by irreversible scarring of the liver that can lead to liver failure and death. Alcohol and chronic viral hepatitis (such as chronic hepatitis B and C) can cause continuous inflammation of the liver, which can lead to excess scar formation or fibrosis. Scarring results in the loss of liver cells and impairs liver function.
the scarring of the liver due to disease or inflammation
A chronic and progressive liver disease characterized by the replacement of normal liver tissue with scar tissue.
Scarring of the Liver, which affects the way it works.
A type of permanent and progressive liver damage. Any chronic liver disease can lead to scarring. Cirrhosis is permanent, but its progress can be stopped.
A condition of scarring or fibrosis of the liver. Some patients with CF experience this condition due to the blockage of the bile ducts with mucus.
Chronic inflammation and degeneration of any organ (normally in the liver)
Disease of the liver, frequently caused by alcohol abuse.
Chronic liver disease that interferes with normal liver function.
Liver disease characterised by death of liver cells, repair processes with nodules (2-10 mm) consisting of scar tissue, giving the liver a rough appearance, and resulting in some patho-physiological events. Most common cause is alcoholism, but may also be caused by hepatitis or other diseases.
A type of chronic, progressive liver disease in which liver cells are replaced by scar tissue.
progressive liver disease, often related to alcohol abuse.
a condition characterized by irreversible scarring of the liver, leading to abnormal liver function. Cirrhosis has a number of different causes, including chronic alcohol use and viral hepatitis B and C. Citric acid cycle: A series of biological reactions that occurs in the matrix of mitochondria in which electrons are transferred to coenzymes and carbon dioxide is formed. The electrons carried by the coenzymes then enter the electron transport chain, which generates a large quantity of ATP. Also called the Krebs cycle.
A disease causing irreversible scarring of the liver.
is probably the most recognized medical complication of chronic alcoholism. It is a grave and irreversible condition characterized by a progressive replacement of healthy liver tissue with scars, which can lead to liver failure and death.
a long term disease of the liver in which the normal liver becomes replaced by fibrous scar tissue and abnormal regenerative nodules of liver cells.
A chronic liver condition caused by scar tissue and cell damage. Cirrhosis makes it hard for the liver to remove poisons (toxins) from the blood. These toxins build up in the blood and may affect brain function. (see Figure 3 below) Figure 3: Normal vs. Cirrhotic Liver
A liver condition characterized by scarring of the liver. Inflammation in the liver may lead to scarring. Scarring can make it difficult for the liver to function. Cirrhosis is a serious medical condition, it can lead to liver failure, liver cancer, and death.
Scar in the liver caused by prior inflammation. May lead to liver failure.
A condition in which specific diseases or conditions cause the liver to become permanently injured and scarred. The scar tissue that forms in cirrhosis harms the structure of the liver, blocking the flow of blood through the organ. The loss of healthy liver tissue slows the liver’s ability to process nutrients and hormones necessary for normal liver function.
Cirrhosis is a liver disease in which the hepatic cells degenerate and the surrounding connective tissues thicken.
disease of the liver characterised by chronic destruction of the normal structure of the organ. Prolonged high alcohol consumption is a common cause of liver cirrhosis.
extensive scarring and destruction of the cells in the liver, often due to excessive alcohol intake.
loss of tissue function of an organ, usually the liver
A chronic disease of the liver characterized by the replacement of normal tissue with fibrous tissue and the loss of functional liver cells
An irreversible, chronic liver disease where normal liver tissue is replaced by connective tissue, resulting in impaired liver function.
Hardening of connective tissue in the liver; fibrosis.
A degenerative disease of the liver ¿ the organ that helps eliminate toxic materials from the body ¿ often caused by alcoholism, but also may result from certain forms of hepatitis. Cirrhosis is characterized by formation of fibrous tissue, nodules, and scarring, which interfere with liver cell function and blood circulation. Symptoms include weakness, weight loss, fatigue, abdominal swelling due to fluid accumulation, and tenderness and enlargement of the liver. Tests for prolonged prothrombin time and decreased albumin are among those used to detect cirrhosis. See prothrombin and albumin.
Fibrosis of the liver with hardening of the organ. This is caused the excessive formation of connective tissue with resultant contraction.
disease of liver characterized by loss of normal microscopic lobular structure
scar tissue replaces normal liver tissue and is accompanied by a decline in liver function; the most advanced form of alcoholic liver injury
A disease in which scar tissue replaces normal, healthy tissue in the liver, blocking the flow of blood through the organ and preventing it from working as it should. Source: National Digestive Diseases information clearinghouse (NDDIC)
Progressive fibrous tissue growth in an organ such as the liver.
A long-term disease in which the liver becomes covered with fiber-like tissue. This causes the liver tissue to break down and become filled with fat. All functions of the liver then decrease, including the production of glucose, processing drugs and alcohol, and vitamin absorption. Stomach and bowel function, and the making of hormones are also affected.
Cirrhosis is a consequence of chronic liver disease characterized by replacement of liver tissue by fibrotic scar tissue as well as regenerative nodules, leading to progressive loss of liver function. Cirrhosis is most commonly caused by alcoholism and hepatitis C, and was the 12th leading cause of death in the United States in 2000, killing about 26,000 people each year. Also, the cost of cirrhosis in terms of human suffering, hospital costs, and lost productivity is high.