A gene whose normal function in the body is unknown. Certain inherited mutations in this gene may markedly increase a person's risk of breast cancer.
The first breast cancer genes to be identified. Mutated forms of these genes are believed to be responsible for about half the cases of inherited breast cancer, especially those that occur in younger women. Both are tumor suppressor genes.
Breast cancer gene 1. It is identified as a gene on the long arm of chromosome 17 which is mutated or lost in 2-4% of women with breast cancer. See also familial breast cancer.
Gene that increases the risk of getting breast, ovarian, bowel or prostate cancer. Out of every 100 women carrying this gene, between 80 and 85 will develop breast cancer at some point in life (80-85% lifetime risk). Ovarian cancer lifetime risk is about 60%. Lifetime risk of bowel cancer and prostate cancer is about 6%. However, most breast cancers (95 out of 100) are sporadic, which means there is no inherited gene involved. If you have cancer, and there are several breast and/or ovarian cancers in your family, it may be possible for you or your relatives to be tested for this gene.
a gene, which, when damaged or mutated, places a woman at much higher risk of developing breast and/or ovarian cancer than the general population.
Genes that normally help to restrain cell growth, but in their altered or mutated form predispose an individual to breast, ovarian, and prostate cancer. Mutations of BRCA1 and BRCA2 are passed down through families or certain ethnic groups.
A gene which, when mutated, leads to an increased risk of both breast and ovarian cancer in those who inherit one copy. .
and BRCA2 genes: The principal genes that, when altered, indicate an inherited susceptibility to breast cancer. These gene alterations are present in 80 to 90 percent of hereditary cases of breast cancer
A gene which, when mutated,increases the risk of developing breast and ovarian cancers.
Two genes that are associated with an increased risk of breast cancer when they have mutations. Every human being has these two genes, which make proteins that are responsible for preventing cancer from forming. When mutations happen in these genes, the protective proteins do not work as well and the individual is then at increased risk of developing cancer. A mutation in the BRCA1/2 genes can be inherited or it can be acquired during our lifetime.
A tumor-suppressing gene. Even if one copy of it is damaged, cancer can develop.
Two mutant genes that are responsible for approximately 50 percent of all inherited forms of breast cancer. Normally these genes are tumor suppressors, which limit the growth of tumors. When mutated, these genes fail to do their job correctly, allowing cancers to grow.
a susceptibility gene for breast cancer
A gene located on chromosome 17 that normally helps to suppress cell growth. Inheriting an altered version of BRCA1 predisposes an individual to breast, ovarian, or prostate cancer.
A gene which is defective in about 2% of women with breast cancer. In a woman with a BRCA1 mutation, the estimated lifetime risk of developing breast cancer is about 50% compared with 12% in the general population.
A gene on chromosome 17 that codes for a protein that normally restrains cell growth. A mutated BRCA1 increases a person's risk of breast and ovarian cancer and possibly of colon and prostate cancer.
A gene located on chromosome 17 that normally produces a protein that normally helps to restrain cell growth.
A harmful change in a BRCA1 or BRCA2 gene that predisposes a person toward developing breast and/or ovarian cancer.
A gene on chromosome 17 that normally helps to suppress cell growth. A person who inherits an altered version of the BRCA1 gene has a higher risk of getting breast, ovarian, or prostate cancer.
a gene which, when damaged (mutated), places a woman at greater risk of developing breast and/or ovarian cancer, compared with women who do not have the mutation. In a woman with a BRCA1 mutation, the estimated lifetime risk of developing breast cancer is about 50% compared with about 12% in the general population. A woman who has this mutated gene has a 50% chance of passing on the gene to each of her children. A genetic test is available, but it is recommended only for women who are known to be at risk because several women in their family have had breast or ovarian cancer at an early age (before menopause). The ACS recommends that any woman tested also receive genetic counseling.
A gene located on chromosome 17 that normally helps to restrain cell growth. Inheriting an altered version of BRCA1 predisposes an individual to breast, ovary, and prostate cancer.
BRCA1 (breast cancer 1, early onset) is a human gene that belongs to a class of genes known as tumor suppressor genes. Like many other tumor suppressor genes, BRCA1 regulates the cycle of cell division by keeping cells from growing and dividing too rapidly or in an uncontrolled way. In particular, it inhibits the growth of cells that line the milk ducts in the breast.