virus of insects used in the production of some HIV vaccines. See Vaccine.
A viral pathogen, such as Autographa californica, that replicates in lepidopteran larvae. Baculovirus expression vectors are widely used for the synthesis of proteins that require post-translational modifications and may be used for the simultaneous synt
A virus that has been used as a cloning vector for the production of recombinant protein in insect cells.
An insect virus which forms the basis of a protein expression system
a class of insect virus used as vectors for recombinant protein expression in insects.
A family of viruses that infect certain insects. They are used to biologically control insects and also have been developed as expression vectors for research and industrial applications. ( see also)
A type of virus that specifically infects insect cells.
Baculoviruses are a class of insect virus which have been used to make DNA cloning vectors for gene expression in eukaryotic cells. Baculoviruses have a gene which is expressed at very high levels late in their infection cycle, filling the nucleus of the cell with many-sided bodies full of a protein which is not needed to produce more viruses, but is necessary for the virus's spread in the wild. In a vector cloning system, this gene is replaced by one that the biotechnologist wants expressed. Production of the protein can be up to 50% of the cells' protein content, and several proteins can be made simultaneously, so that multi-sub-unit enzymes can be made by this system. Being an animal expression system, baculoviruses produce proteins that are glycosylated (addition of carbohydrates) like the proteins in animals, making it an attractive option for the production of biopharmaceuticals. In addition, baculoviruses are non-infective and non-pathogenic to vertebrates.
an insect virus used in the production of subunit vaccines. By splicing a specific HIV gene(s) into the baculovirus genome, and then combining this construct with insect cells, mass quantities of the purified HIV protein(s) coded for by these two HIV gene(s) can be made by the cells for use as a vaccine. (See also expression system.)
A group of viruses that infect insects; has double-stranded DNA, rod-shaped. Includes the nuclear polyhedrosis, granulosis, and Oryctes viruses.
The http://www.ncbi.nlm.nih.gov/ICTVdb/Ictv/fs_bacul.htm baculoviruses are a family of large rod-shaped viruses that can be divided to two genera: nucleopolyhedroviruses (NPV) and granuloviruses (GV). While GVs contain only one nucleocapsid per envelope, NPVs contain either single (SNPV) or multiple (MNPV) nucleocapsids per envelope. The enveloped virions are further occluded in granulin matrix in GVs and polyhedrin for NPVs.