Protein subunit of chylomicrons that transport cholesterol and fatty acids through the bloodstream. Alterations of this protein affect the binding and release of fatty acids and cholesterol, especially at the site of lipoprotein lipase at the blood brain barrier. One gene variant, ApoE4, is considered a genetic risk factor for AD. Approximately 50% of diagnosed AD patients are ApoE4+ and have an alteration of their chylomicrons that causes fatty acids and cholesterol to be more tightly bound and less available for the brain.
a gene that has been linked to an increased risk of Alzheimer's disease. People with a variant form of the gene, called apoE epsilon 4, have about ten times the risk of developing Alzheimer's disease.
a protein that carries cholesterol in blood and that appears to play some role in brain function. The gene that produces ApoE comes in several forms, or alleles - e2, e3, and e4. The APOE e2 allele is relatively rare and may provide some protection against AD. APOE e3 is the most common allele and it appears to play a neutral role in AD. APOE e4 occurs in about 40 percent of all AD patients who develop the disease in later life; it increases the risk of developing AD.
A type of lipoprotein (a protein connected to a fat). Apolipoprotein E is abbreviated ApoE and the gene that encodes it is known as APOE. APOE is located on chromosome 19 in band 19q13.2. See the entire definition of Apolipoprotein E
certain alleles of the gene which encodes the protein apolipoprotein E have been reported to be associated with the development of heart disease and Alzheimer's disease.
a gene situated on chromosome 19 that codes for a protein in lipoproteins that are normal constituents of blood plasma, for example HDL (high density lipoprotein), LDL (low density lipoprotein), and VLDL (very low density lipoprotein). There are a number of common variations (alleles) of the APOE gene, the most common of which are known as: e2, e3, and e4. Research has shown that people who inherit one or more copies of the APOEe4 gene are at increased risk of developing Alzheimer's disease. Meanwhile, there is evidence to suggest that the relatively rare APOEe2 allele may offer some protection against the disease - it seems to be associated with a lower risk for Alzheimer's and a later age of onset if the disease does develop. APOEe3 is the most common form of the gene in the general population and is thought to have no effect on Alzheimer's risk.
A protein whose main function is to transport cholesterol. The gene for this protein is on chromosome 19 and is referred to as APOE. There are three forms of APOE: e2, e3, and e4. APOE-e4 is associated with about 60 percent of late-onset Alzheimer’s cases and is considered a risk factor for the disease. apoptosis Programmed cell death.
A gene that codes for a protein in lipoproteins (complexes of fat + protein). The abbreviation for apolipoprotein E is ApoE.
Apolipoprotein E (APOE), a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. APOE http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12495081is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. APOE was initially recognized for its importance in lipoprotein metabolism and cardiovascular disease.