Definitions for "Angelman syndrome"
A combination of birth defects caused by inheriting both copies of the #15 chromosome from the father.
a genetic disorder characterized by mental retardation, hyperactivity, and unprovoked laughter
A rare syndrome reported in 1965 by Dr. H. Angelman and associated with a chromosome 15 deletion similar to that seen in PWS. In AS, however, the deletion is seen on the chromosome contributed by the mother, whereas those with PWS lack certain genes from the father. The clinical problems and appearance of AS and PWS are distinctly different. These two syndromes represent the first examples in humans of genetic imprinting.