Kane is a fictional and prominent character from Westwood Studios' benchmark Command & Conquer series real-time strategy video games, and the nefarious and seemingly immortal mastermind behind the ancient and secretive Brotherhood of Nod society. Little is truly known about him; many of his followers draw a connection between him and the biblical figure of Cain, which Kane does not go out of his way to confirm or deny.

Kane is a Dutch pop group. The two original members were Dinand Woesthoff (singer) and Dennis van Leeuwen (guitarist). They added drummer Martijn Bosman in 2002.

Kane is a fictional character from the Highlander movies, portrayed by actor Mario Van Peebles. He is an Immortal.

KANE is an American country, southern rock, and Americana band that was formed in 1998 in Los Angeles, California. The band has released two successful independent albums and toured both the U.S. and Europe. They are currently working on their first studio album after signing a deal with RCA Nashville in the late-Spring of 2006.

Kane is a literary character created by Karl Edward Wagner in a series of sword and sorcery novels and short stories between 1970 and 1985. The stories are set in a grim, pre-medieval world which is nonetheless ancient and rich in history. In some of Wagner's later stories Kane appears in the present day  — for example, as a drug dealer in "Lacunae" and as a somewhat suspect publishing magnate in "At First Just Ghostly".

Kane is a British spanking magazine, originally published in the UK by the late Harrison Marks. First published in 1982, it claims to be the longest-published British spanking magazine. A veteran of the UK glamour scene Harrison Marks saw this magazine (covering an area in which he, apparently, had no personal interest) as a way of out the financial troubles he found himself in.

Kane is a two-dimensional action game by Mastertronic, published in 1986. The game runs on Amstrad CPC, Commodore 64 and Sinclair ZX Spectrum.