The process by which segments of DNA are exchanged between two DNA duplexes that share high sequence similarity.
The physical exchange of DNA between two homologous DNA molecules. Requires the RecA protein in enteric bacteria. Also called general recombination.
a process whereby a specific gene sequence within the genome is replaced with a related gene sequence using the cellular recombination enzymes
A process by which one DNA segment can replace another DNA segment that has a similar sequence. Homologous recombination is used by researchers to create "knockout" mice in which the function of a specific gene is disrupted.
The substitution of a segment of DNA with one that is identical or almost identical to it. It occurs naturally during meiosis, but can also be used experimentally for gene targeting to modify the sequence of a gene.
Recombination between two homologous double-stranded DNA molecules, that is, ones which share extensive nucleotide sequence similarity.
A term generally used in genetic engineering where an experimentally modified allele is substituted for a normal allele in somatic cells, utilizing the enzymes involved in DNA repair and replication; Formation of new combinations of alleles involving exchange of homologous loci.
Rearrangement of related DNA sequences on a different molecule by crossing over in a region of identical sequence.
The exchange of DNA fragments between two DNA molecules or chromatids of paired chromosomes (during crossing over) at the site of identical nucleotide sequences.
The exchange of pieces of DNA during the formation of eggs and sperm. Recombination allows the chromosomes to shuffle their genetic material, increasing the potential of genetic diversity. Homologous recombination is also known as crossing over.
exchange of genetic material between two DNA fragments presenting sequence homologies
the process of replacing one DNA segment with a similar sequence.
Swapping of DNA fragments between paired chromosomes.
genetic recombination that requires extensive sequence homology between the recombining DNA molecules. Meiotic recombination by crossing over in eukaryotes is an example.
Exchange of chromosomal DNA, by recombination or "crossing over" for another stretch of DNA which is homologous or similar. However, in gene manipulation experiments the replacement DNA has been subtly altered to affect the properties of the transcribed/translated product.
Technique used to introduce exongenous genetic material into recipient nucleus based on DNA homology.
The process by which a DNA sequence can be replaced by one with a similar sequence to determine the effect of changes in DNA sequence in the process of site-directed mutagenesis.