The power possessed or acquired by some persons of bearing doses of medicine which in ordinary cases would prove injurious or fatal.
the acquired inability to respond with an immune reaction to an antigen to which the organism normally responds; -- called also immunotolerance, immunological tolerance, or immune tolerance. Such tolerance may be induced by exposing an animal to the antigen at a very early stage of life, prior to maturation of the immune system, or, in adults, by exposing the animal to repeated low doses of a weak protein antigen (low-zone tolerance), or to a large amount of an antigen (high-zone tolerance).
Decrease in response to a fixed dosage of drug; over time, higher and higher doses of a drug are needed to get the desired effect
occurs when there is a need to increase the dose of the drug in order to achieve the same initial effect.
A state of adaptation in which exposure to a drug induces changes that result in a diminution of one or more of the drug's effects over time.
metabolic and physiologic adaptation of the body to effects of a drug requiring increased dose and/or more frequent administrations.
If a person takes a particular drug (or medicine) over some time, the drug may gradually become less effective as their body may respond less to it. This is known as drug tolerance. If this happens, it may be necessary either to increase the dose or change to another drug.
in pharmacology, refers to the reduced responsiveness to a drug's action as the result of previous continued and/or multiple exposure
in reference to Medication, refers to the body becoming less responsive to a particular dosage of medication. Accordingly, to maintain the effect of medication, dosage needs to be increased.
The need for increased amounts of alcohol or other substance to achieve intoxication or the desired effect; or diminished effects with continued use of the same amount of alcohol or other drug; or demonstrating adequate functioning at levels of alcohol that would produce significant impairment in a casual user.
The need for greater doses of a chemical substance like alcohol to experience its effects. The body's adjustment to the frequent presence of alcohol or other drugs results in a need to increase the dosage to attain the sought-after change of feelings or " high". A high tolerance is the ability to drink a large quantity of alcohol without showing signs of impairment, which also indicates a problem with or the development of alcoholism. Reference: A1
What results from prolonged recent use of drugs requiring one to use more to get the same effect. "I've built up a tolerance to LSD, now I have to take at least 500 mikes to get off."
Where modification of the environment by early occupants has little or no effect on subsequent performance of late-successional species.
A characteristic of substance dependence that may be shown by the need for markedly increased amounts of the substance to achieve intoxication or the desired effect, by markedly diminished effect with continued use of the same amount of the substance, or by adequate functioning despite doses or blood levels of the substance that would be expected to produce significant impairment in a casual user.
A physiological process in which greater and greater amounts of an addictive drug are required to produce the same effect. See substance dependence.
Refers to a drug that becomes less effective the more times it's used.
The capacity of a drug to produce a gradually diminished physical or psychological effect upon repeated administrations of the drug at the same dose level” ( Levinthal, 29).
The need to take increasingly large amounts of chemicals in order to achieve the desired effects; the same effects previously achieved by smaller amounts.
A decreased response to alcohol, usually over a period of prolonged exposure.
A decreased responsiveness to the adverse effects of a chemical, biological or physical agent.
The first time a person uses a drug, they have a very low tolerance and are likely to feel the effects very strongly. The more often the drug is used, generally the less intense the effects will be. This results in the need to take larger amounts to get the desired effect
The ability to cope with the physical, emotional, and cognitive effects of alcohol or other drug use.
The capacity to absorb a drug continuously or in large doses with no adverse effects.
A gradual decrease in the body's response to a drug, thereby requiring large and larger doses to achieve the same effect.
The decreased sensitivity of the body to a certain drug, usually either because the liver becomes more efficient at breaking down the drug or the body's tissues become less sensitive to it; increased tolerance creates a need for a higher dose of the drug in order to have the same effects.
A common physiologic result of chronic opioid use; it means that a larger dose of opioid is required to maintain the same level of analgesia.
A condition in which higher and higher doses of a drug are needed to produce the original effect or high experienced.
Tolerance to a drug means that a person needs more of the drug in order to achieve the same effect they felt previously with smaller amounts.
power to resist action of drug without being affected.
Increasing dosages are required over time to maintain the medication's effect.
Decreased sensitivity to the effects of a substance such as a medication.
A condition in which the body becomes used to a substance and needs greater quantities to produce the same effect.)
the reduced effect of an agent on the body, due to repeated use.
a condition in which the body becomes accustomed to an agent (e.g., drug) so that the previous dose no longer produces the desired effects and a progressively larger dose is needed to achieve a previously observed effect. See also cross-tolerance.
Reduced response of the organisms and increased capacity to support its effects after a more or less lengthy period of use. Tolerance levels are extremely variable between substances, and tolerance to cannabis is believed to be lower than for most other drugs, including tobacco and alcohol.
refers to the way the body gets used to the repeated presence of a drug, meaning that higher doses are needed to maintain the same effect. The body learns to tolerate the drug in the system.
This condition occurs when the initial dose of a substance loses its effectiveness over time.
The ability of a person to adapt their behavior to disguise the effects of alcohol.
The condition wherein a drug user requires increasingly larger amounts of the drug to produce the same effect. A change in the system of the user, developing with prolonged or increased use of a drug.
Drug is no longer effective at the present dose because the body had adjusted and now needs a higher dose.
condition in which the body tries to overcome the effects of a drug, therefore developing resistance to that drug; although the drug may work initially, after time, it no longer causes the original intended effect
A state in which the body's tissue cells adjust to the presence of a drug. The term "tolerance" refers to a state in which the body becomes used to the presence of a drug in given amounts and eventually fails to respond to ordinarily effective dosages. Therefore, larger doses are necessary to produce desired effects.
Physiological adaptation to the effects of the drugs, so as to diminish effects with constant dosages or to maintain the intensity and duration of the effects through increased dosage. (1)
the increased ability of an organism to resist the effects of a toxic substance
Decreasing effect of a drug with the same dose or the need to increase the dose to maintain the same effect.
A state in which an increased dosage of a psychoactive substance is needed to produce a desired effect.
When higher doses of a drug are required to produce the initial high. Long term use will commonly result in high tolerance, which invariably leads to physical dependence.
body adaptation to repeated drug effects requiring increased dosage for original experiences.
Adaptive state characterized by diminished effects of a particular dose of a substance: the process leading to tolerance is called "adaptation" In food toxicology, dose that an individual can tolerate without showing an effect Ability to experience exposure to potentially harmful amounts of a substance without showing an adverse effect Ability of an organism to survive in the presence of a toxic substance: increased tolerance may be acquired by adaptation to constant exposure. In immunology, state of specific immunological unresponsiveness
A decrease in response to a drug dose that occurs with continued use. An increase in the dose of a drug is required to achieve the effects originally produced by lower doses.
The need for increased amounts of a substance to obtain a desired effect or a decreased effect over time from the same quantity of a substance.
resistance to the effects of a pharmacological agent as a result of sustained or large-dose exposure to the agent.
A condition in which higher doses of a drug are required to produce the same effect as experienced initially.
A condition in which higher doses of a drug are required to produce the same effect as during initial use; often leads to physical dependence.
Tolerance has developed when after repeated administration, a given dose of a drug produces decreased effect, or conversely, when increasingly larger doses must be administered to obtain the effects observed with the original use.
To prevent the effects of certain things.
the loss of activity of a drug, requiring higher doses to maintain the same effect.
The body's ability to adapt to chronic alcohol or substance use. Higher BACs are needed to produce intoxication in alcohol abusers and alcoholics. Chronic alcohol use leads to increased levels of liver enzymes that metabolize alcohol. Since they allow the liver to more efficiently break down alcohol, the individual must consume a larger dose to reach a given BAC. This increased level of alcohol can severely damage the body's physiological systems, despite the apparent "normalcy" displayed by the individual.
The need to take more and more of a drug to achieve the same effect. An important factor in drug dependence.
Tolerance in pharmacology refers to the decreased responsiveness to a drug's action as the result of earlier continued use.
A physiological change resulting from repeated drug use that requires the user to consume increasing amounts of the drug to get the same effect a smaller dose used to give.
needing more of the drug to get the same effect