a powerful and efficient method for rapid genomewide linkage scans in autosomal recessive diseases in inbred populations, where affected individuals are likely to be homozygous for alleles at loci surrounding the disease gene

a practical way to reduce the cost of large-scale case-control association studies, because it allows measurement of allele frequencies in groups (or pools) of individuals, thereby reducing the number of PCR reactions and genotyping assays dramatically

a reliable and cost-saving alternative genotyping method

a technique to reduce genotyping effort while incurring only minor losses in accuracy of allele frequency estimates for single nucleotide polymorphism (SNP) markers

The equimolar combination of many individuals from a population into a single sample. Used for rapid allele frquency determination.