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Keywords:
Unspecialised,
Embryonic,
Undifferentiated,
Immature,
Stem
The gradual formation or production of organs or parts by a process of evolution or development, as when the seed develops the root and the stem, the initial stem develops the leaf, branches, and flower buds; or in animal life, when the germ evolves the digestive and other organs and members, or when the animals as they advance in organization acquire special organs for specific purposes.
The maturing of cells from immature cancer susceptible cells to mature cancer resistant cells.
Process whereby originally similar cells follow different developmental pathways. The actual expression of determination.
A technique of identifying subclasses in a class hierarchy whereby the subclasses define the exceptions and special cases of the superior class. Contrast with generalization.
Specialization of general cells, tissues, or organs to specific function. A process of development toward a complex state. Organs initiate at the meristem as undifferentiated cells but differentiate toward a mature state.
Process of change in which stem cells divide and mature to form fully functioning specialised cells
The process by which stem cells transform from cells without a specific structural or functional characteristics into functional cells of a single blood cell line. The process of differentiation of stem cells forms the red blood cells, platelets, neutrophils, monocytes, eosinophils, basophils and lymphocytes.
The specialization of characteristics or functions of cell types.
In cancer, it refers to how mature the cancer cells are. Well-differentiated cancer cells are more like normal cells, usually less aggressive and respond better to treatment. Undifferentiated cells are not able to carry out normal cell functions. In cancer, undifferentiated cells are often more aggressive, but, paradoxically, can be more sensitive to anti-cancer treatments.
The process in which scientists influence the manipulation of stem cells through different signals or chemicals. EMBRYO: A fertilized egg that has begun to divide but is still in the earliest stages of development.
the gradual maturation of a cell whereby its functions and properties become increasingly: specialised. Leukaemic cells are often poorly differentiated, i.e. They show immature characteristics.
Process of formation of specialized cells from the parental cell.
The acquisition of specialized structural and functional features by unspecialized cells.
progressive changes in cell, tissue, or organ structure and function during development, usually from simple to more complex.
The process by which cells develop into specialized tissues and organs.
The sinking of relatively heavy elements into the core of a planet or other body. Differentiation can occur only in fluid bodies, so any planet that has undergone this process must once have been at least partially molten. Also, a process whereby a stem cell acquires the characteristic features of a given cell type.
the process cells undergo as they mature into normal cells. Differentiated cells have distinctive characteristics, perform specific functions, and are less likely to divide. Breast cancer originates in cells that are not differentiated
The modification of a cell in terms of structure and/or function occurring during the course of development.
In the general sense, the increasing specialization of organization of the different parts of an embryo as a multi-cellular organism develops from the undifferentiated fertilized egg. Referring to cells, the development of cells with specialized structure and function from unspecialized precursor cells, which occurs in embryonic development and in the subsequent replacement of certain types of cell from persisting unspecialized stem cells. See also Cell.
This describes the changes in the form and function of cells during development, which enables them to carry our specialised tasks.
The growth of cells into a specific type of cell.
The process by which cells become specialized into the various tissues of the body. Usually first detectable within the first few cell divisions after fertilization as the cells of the early embryo loses the ability to generate a complete adult organism if separated from each other.
1. in cell biology, a process in which cells and tissues become specialized for specific roles. For example, stem cells in the small bowel crypts differentiate into enterocytes. 2. in a neoplasm, the extent to which cells have the structure and function of the mature normal cells of the tissue of origin. The degree of differentiation is sometimes used to grade tumours.
The development of cellular specialization as cells mature.
(dif-er-en-she-A-shun) : the normal process through which cells mature so they can carry out the jobs they were meant to do. Cancer cells are less differentiated than normal cells. Grading is done to evaluate and report the degree of a cancer's differentiation.
the acquisition of specific functions different from those of the original general type
development of specific cell types from stem cells by gene activation and repression.
the process of changing from an original unspecialized form to a different, more specialized form; e.g. the differences between prostate cancer cells are examined under the microscope as a method to grade the severity of the disease.
Process by which a cell undergoes a change to an overtly specialized cell type.
The process in which cells mature and become specialized.
The level of maturity of cancer cells in a tumor. Differentiated tumor cells resemble normal cells and grow at a slower rate than undifferentiated tumor cells.
The extent to which the cancerous cells resemble normal cells - less resemblance means the cancer is less differentiated and more aggressive.
The process of change from an unspecialised cell into a specialised one. The cell's structure and function may change. In vertebrates, most cells in the embryo are not yet differentiated. During embryonic development, cells differentiate into different types, such as nerve, muscle or blood cells. Once differentiated, these cells cannot usually change back into ‘generalised' cells.
A process that occurs when immature cells cease dividing and assume a specific function, such as secreting mucous or contraction.
(biology) the structural adaptation of some body part for a particular function; "cell differentiation in the developing embryo"
The process by which stem cells transform from cells without specific characteristics into cells of a single blood cell line. The red cells, platelets, neutrophils, monocytes, eosinophils, basophils, or lymphocytpes are formed by this process.
The process by which cells mature and become specialized.
Method to grade the severity of disease based on the differences between prostate cells examined microscopically. Well-differentiated cells are easily recognized as normal cells, while poorly differentiated cells are abnormal, cancerous and difficult to recognize as belonging to any particular type of cell group.
The process by which cells and tissues undergo a series of changes resulting in their specialisation to a specific form or function. A differentiated cell such as a muscle cell or a skin cell contains a full set of genes of that organism, but only expresses the genes necessary for its specific function. In animals, stem cells (both embryonic and adult) are the only cells capable of undergoing differentiation to form more specialised cell types found in the body.
in higher organisms there are different types of cells each fulfilling specialised functions. The process by which the specialised cells are created is called differentiation
The process by which abnormal or immature cells are distinguished by individual characteristics which are attributes of normal cell types
The process by which early unspecified cells acquire the features of specific cells such as heart tissue, liver or muscle.
The development of cells with specialised structure and function from unspecialised precursor cells.
The normal, biological process by which cells become structurally and functionally specialized during the developmental cycle toward maturation. Cellular differentiation is due to changes in appearance, or morphology, and not through genetic changes. Back to glossary index
The process of transition from stem cell to specialized cell, such as a blood, heart or bone cell.
A series of steps that cells go through to reach their mature state.
A process through which a single type of cells (e.g., stem cells) becomes different types of cells with special functions.
the process of specialisation of cell structure and function during an embryos development
( biol.) - The process by which cells reproduce different characteristics. Genes are turned off or on in order to cause change, otherwise all cells would be exact duplicates of one another.
The maturation of a stem cell into a functional cell
the process by which stem cells acquire the features of specialized adult cells such as those found in heart, brain and pancreatic tissue.
The sum of the processes whereby apparently indifferent cells, tissues and structures attain their adult form and function.
Divergence in structure and function of cells as they become specialized during a multicellular organism's development; depends on the control of gene expression (cell differentiation).
In cells, the process of changing from the kind of cell that can develop into any part of the body to a cell of one specific kind.
The developmental process by which an unspecialized cell undergoes a progressive change to a more specialized cell.
refers to the maturation stage of the atypical cells. Blood cells go through phases of development, or stages of maturation, just a human being go through stages: infant, child, adolescent ... The process of maturation of cells is called differentiation - how the cell changes, or the differences in what the cell expresses at each stage. (not unlike: infant = bald, child = thin hair, adolescent = curly hair, old age = bald, etc. )
The process by which early unspecified cells acquire the features of specific cells such as heart, liver, muscle, or brain tissue.
The acquisition of particular structures and characteristics by cells or tissues which allows them to perform specific functions. Loss of cell differentiation is a defining characteristic of cancer.
The process by which less specialised cells develop into more specialised cell types.
Process by which cells change in structure in order to carry out specific functions.
The use of the differences between prostate cancer cells when seen under the microscope as a method to grade the severity of the disease
The process that an unspecialized early embryonic cell obtains the characteristics of a specialized cell such as a heart, spleen, or muscle cell.
(of cells or tissues) to change from relatively generalized to specialized kinds, during development.
The process of biochemical and structural changes by which cells become specialized in form and function.
process usually involving changes in gene expression by which a precursor cell becomes a distinct specialized cell type.
the degree of similarity of tumour cells to the organ from which they originated. A well differentiated cell is highly specialised, structurally highly organised and clearly recognisable. A poorly differentaied cell is structurally poorly organised and difficult to recognise. Grading tumours in this way is of prognostic value, poorly differentaited tumours having a higher risk of distant metastases/poorer survival.
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