John Nathan Henderson (born January 9, 1979, Nashville, Tennessee) is an American Football player who currently plays Defensive Tackle for the Jacksonville Jaguars of the NFL. He recently signed a 6-year contract extension to stay put in Jacksonville. He was selected to the Pro Bowl following the 2004 season.

John Henderson is a British film and television director.

John Henderson was elected mayor of Ludington, Michigan in 2002 defeating incumbent Mayor Carol Pomorski. During his tenure, Henderson has created a Youth Advisory Council and made it a priority to revitalize downtown Ludington. In 2006, he made it a priority to create a Skate Park near the Lake Michigan beach in Ludington.

John Henderson is Professor of Classics at Cambridge University, and a Fellow of King's College, Cambridge. He has written widely on all aspects of Latin Literature and is commonly regarded as one of the most subversive and idiosyncratic Latinists of his generation. His books include "Writing Down Rome" and "Fighting for Rome".

John Henderson (12 July 1888 – 28 May 1975) was a Scottish Conservative party politician.

John Henderson (February 28, 1797 - September 15, 1857) was a Mississippi lawyer and politician. Born in Cumberland County, New Jersey, he later emigrated to Mississippi, where he practiced law in Woodville. In 1835, he was elected to the State Senate, and was later elected to the United States Senate as a Whig, serving one full term.