Sir John Middleton (1870 – 1954) was a British colonial administrator.

John Middleton (1820-1885) was an English architect in the 19th Century. He was born in York, in August 1820.

John Middleton (1578-1623) was an English giant commonly known as the Childe of Hale. Most of what is known about him is based on oral tradition and legends.

John Middleton (born September 7, 1953 in Bradford) is an English actor well known for his part in ITV's Emmerdale as Reverend Ashley Thomas. He has also appeared in many other TV programmes, most notably as John Hargreaves in Coronation Street, the man who knocked down and killed Lisa Duckworth.

John Middleton was friend of Billy the Kid and a key member of The Regulators, who fought on behalf of John Tunstall during the Lincoln County War.

John Middleton (1678-1739) was a Scottish politician and Member of Parliament who was burgh of the Aberdeen (UK Parliament constituency) in Aberdeen Scotland between 1708 and 1710.