Simon Fraser (1776–18 August 1862) was a fur trader and an explorer who charted much of what is now the Canadian province of British Columbia. Fraser was employed by the Montreal-based North West Company and by 1805 had been put in charge of all the company's operations west of the Rocky Mountains. He was responsible for building that area's first trading posts, and in 1808 he explored what is now known as the Fraser River, which bears his name.

Simon Fraser is a British comics artist best known for his work on Nikolai Dante, a series he created with writer Robbie Morrison in 2000 AD.

Sir Simon Fraser (21 August 1832 - 30 July 1919), Australian politician, was a member of the Australian Senate and the grandfather of Malcolm Fraser, Prime Minister of Australia from 1975 to 1983.

Simon Fraser of Oliver and Neidpath, Knight Banneret fought in the Wars of Scottish Independence.

Simon Fraser (born March 27, 1983 in Upper Arlington, Ohio) is an American football player who currently plays defensive end for the Cleveland Browns. At Ohio State University, Fraser was a three-time OSU Scholar-Athlete selection and a two-time Academic All-Big Ten Conference honoree, as well as a co-captain as a senior. He was signed as an undrafted free agent by the Browns on April 29, 2005.