The fifth USS Truxtun (DLGN-35/CGN-35) was a nuclear powered cruiser in the U.S. Navy. She was launched as a destroyer leader and later reclassified as a cruiser.

Six ships of the United States Navy have been named USS Truxtun, after the early naval hero Thomas Truxtun.

USS Truxtun (DDG-103) is a US Navy Arleigh Burke-class destroyer currently under construction. Her keel was laid down on April 11 2005.

The second USS Truxtun (DD-14) was the lead ship of her class of destroyers in the United States Navy. She was named for Thomas Truxtun.

The third USS Truxtun (DD-229) was a Clemson-class destroyer in the United States Navy during World War II. She was named for Thomas Truxtun.

The first USS Truxtun was a brig in the United States Navy.