Nemesis is a science fiction novel by Isaac Asimov. One of his later science fiction novels, it was published in 1989, only three years before his death. The novel is loosely related to the future history into which he attempted to integrate his science fiction output, connecting several ideas from earlier and later novels, including non-human intelligence, sentient planets (Erythro), and rotor engines (Fantastic Voyage II: Destination Brain).

Nemesis is the name of two fictional characters in the DC Comics universe.

The Nemesis is a Decepticon spaceship in the fictional Transformers Generation One universe. It was built by Megatron as the flagship of his Decepticon space fleet, and was described by Optimus Primal as the most powerful Decepticon battleship ever. The ship was never named in the original series, only being given a name in the Beast Wars series finale.

Nemesis is the name of three fictional superheroines in the Marvel Comics universe.

Nemesis (published in 1971) is a detective fiction novel by Agatha Christie, featuring her detective Miss Marple. It was the last Miss Marple novel the author wrote, although not the last published.

Nemesis was a robot competing in the first 2 Series of Robot Wars.

Nemesis is a 1993 science fiction film by director Albert Pyun, who also made the movie Cyborg.

Nemesis is an original novel based on the U.S. television series Angel.

Nemesis is an operating system designed by the University of Cambridge, the University of Glasgow, the Swedish Institute of Computer Science and Citrix Systems.