Timolol maleate is a non-selective beta-adrenergic receptor blocker. In its oral form (Blocadren®), it is used to treat high blood pressure and prevent heart attacks, and occasionally to prevent migraine headaches. In its ophthalmic form (brand names Timoptol® in Italy; Timoptic®), it is used to treat open-angle and occasionally secondary glaucoma by reducing aqueous humour production through blockade of the beta receptors on the ciliary epithelium.