'TES' (aka 'Testin') is the protein product of the TESS gene, located on chromosome 7 Tatarelli C, et al, (2002) Characterization of the Human TESTIN Gene Localized in the FRA7G Region at 7q31.2, Genomics, 68, P 1-12 in Homo sapiens. TES is a 47 k Da protein composed of 421 amino acids found at focal adhesions and is thought to have a role in regulation of cell motility. Coutts, AS et al, TES is a novel focal adhesion protein with a role in cell spreading, (2003) Journal of Cell Science 116, 897-906 In addition to this, TES functions as a tumour suppressor Drusco, A et al, Knockout mice reveal a tumor suppressor function for Testin, (2005) Proc Natl Acad Sci U S A 102 p10947–10951.; the TESS gene is located within a fragile region of chromosome 7, and the promoter elements of the TESS gene have been shown to be susceptible to methylation - this prevents the expression of the TES protein.