Smoothened is a 7 TM protein of the hedgehog pathway conserved from flies to humans. It is the molecular target of the teratogen cyclopamine.Taipale J, Chen JK, Cooper MK, Wang B, Mann RK, Milenkovic L, Scott MP and Beachy PA. (2000) Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine. Nature, 406:1005-9.

made smooth by ironing