Vasodilating substance that is formed in the endothelium; prostacyclin and its derivatives are used as infusions in the treatment of pulmonary arterial hypertension. ; a potent inhibitor of platelet aggregation, also causes vasodilation

the prostaglandin hormone PGI2, a natural hormone made by normal artery wall lining cells (intima) to inhibit the formation of abnormal blood clots. Peroxidized lipids can block prostacyclin manufacture, thus fostering the development of blood clots.

Generated from arachidonic acid in endothelial cells of the cardiovascular system; acts as strong vasodilator and is involved in clotting.

Prostacyclin is a member of the family of lipid molecules known as eicosanoids. A synthetic form of prostacyclin, used as a medicine, is referred to as epoprostenol. It is produced in endothelial cells from prostaglandin H2 (PGH2) by the action of the enzyme prostacyclin synthase.