Autoimmune attack causing liver damage.
An uncommon form of liver disease where small bile ducts within the liver become inflamed and destroyed. Symptoms occur late in the disease and the diagnosis is often made because of abnormal blood tests. Backup of bile and bile byproducts into the intestine causes intense skin itching and yellowing of the skin (jaundice). Lack of bile decreases absorption of calcium and vitamin D leading to osteoporosis. Cirrhosis (scarring of the liver) develops over time. PBC mostly affects women in middle age and is thought to be an autoimmune disease (disease where the bodyâ€(tm)s self defense system does not recognize the bodyâ€(tm)s tissues and attacks them). A drug, ursodeoxycholic acid, may delay transplant.
A long-term, progressive disease that destroys the bile ducts inside the liver.
A slowly progressive disease of the bile ducts inside the liver. Inflammation of the bile ducts can eventually lead to scarring and this can sometimes cause blockage and a back flow of bile.
A condition of the liver in which the microscopic bile ducts are destroyed by the body's immune system. Eventually, patients will require liver transplantation.
chronic liver disease; slowly destroys the bile ducts in the liver, which prevents release of bile. Long-term irritation of the liver may cause scarring and cirrhosis in later stages of the disease.
An inflammatory condition of bile ducts resulting in narrowing and obstruction of the flow of bile, causing damage to liver cells. Bile ducts within the liver become inflamed due to an unknown cause. The onset of symptoms is gradual, most commonly with fatigue and itching skin as the first symptom. Long-standing bile obstruction is believed to lead to liver cirrhosis. The disease may be associated with autoimmune disorders. The disease more commonly affects middle-aged women.
A disease that slowly destroys the bile ducts in the liver. When the ducts are damaged, bile (a substance that helps digest fat) builds up in the liver and damages liver tissue.
a chronic disease that causes a progressive destruction of bile ducts in the liver
A chronic liver disease. Destruction of the bile ducts in the liver prevents release of bile.
chronic cholestatic liver disease that progresses slowly towards a terminal phase characterized by jaundice, signs of decompensated cirrhosis, ascites and variceal bleeding.
Primary biliary cirrhosis is an autoimmune disease of the liver marked by the slow progressive destruction of the small bile ducts (bile canaliculi) within the liver. When these ducts are damaged bile builds up in the liver (cholestasis) and over time damages the tissue. This can lead to scarring, fibrosis, cirrhosis, and ultimately liver failure.