a metabolic condition characterized by congenital reduced muscle tone, overeating, obesity and mental retardation. The syndrome is associated with below normal secretion of gonadotropic hormones by the pituitary gland.
A congenital disorder causing facial anomalies, slow height growth, low muscle tone, obesity which begins between one and three years of age, and mental retardation. For more information, follow this link to a site about Prader-Willi Syndrome.
PWS is a complex genetic disorder that includes short stature, mental retardation or learning disabilities, incomplete sexual development, characteristic behavior problems, low muscle tone, and an involuntary urge to eat constantly, which, coupled with a reduced need for calories, leads to obesity. www.thearc.org/faqs/pwsynd.html
a genetic disorder marked by hypotonia, short stature, hyperphagia and cognitive impairment.
A chromosomal disorder. Symptoms may include short stature, mental retardation, obesity, and lack of sexual development.
A genetic disorder caused by a missing part or all of chromosome 15, which results in dystonia (lack of muscle tone), small hands and feet, and mental retardation. Some common facial characteristics include almond-shaped eyes, thin lips, and full cheeks.
A combination of birth defects caused by inheriting both copies of a section on the #15 chromosome from the mother or by inheriting a deletion of a region of chromosome #15 from the father.
An uncommon, non-inherited birth defect with unknown causes. It is characterized by low muscle tone, insatiable appetite, developmental delays, variable degrees of mental retardation, short stature, in adults, small hands and feet and behavior problems which can be severe.
An inherited condition typified by hypotonia (deficient muscle tone). Most children with Prader-Willi Syndrome have intellectual limitations, though some are of average abilities. Caloric intake must be closely monitored because of the rapid and severe obesity that can occur with this condition. From the age of about 6 years onward, many children present scars from scratching due to itching. Depigmentation and decreased sensitivity to pain are a common occurrences in individuals with this syndrome. A frequent feature is thick saliva at the edges of the mouth. Psychotic illness in early adult life can also occur with this syndrome.
Prader-Willi Syndrome is a genetic disorder in which seven genes (or some subset thereof) on chromosome 15 are missing or unexpressed (chromosome 15q partial deletion) on the paternal chromosome. It was first described in 1956 by Andrea Prader, Heinrich Willi, Alexis Labhart, Andrew Ziegler, and Guido Fanconi of Switzerland. The incidence of PWS is between 1 in 12,000 and 1 in 15,000 live births.