Podophyllin is a resinous powder obtained by precipitating an alcoholic tincture of the rhizome of American Mayapple (Podophyllum peltatum) by means of water acidulated with hydrochloric acid. It varies in color from grayish to bright yellow or greenish-brown, the first-named being the purest. The powder is soluble in alcohol and strong solutions of alkalis, such as ammonia.