The papaya, also known as mamao, tree melon, lechoza (Venezuela), or pawpawis the fruit of the tree Carica papaya, in the genus Carica. Originally from southern Mexico, Central America and northern South America, the papaya is now cultivated in most tropical countries. Papaya is rich in an enzyme called papain (a protease which is useful in tenderizing meat) and other proteins. Its utility is in breaking down the tough meat fibers and it has been utilized for thousands of years in its native South America. It is included as a component in powdered meat tenderizers. Papaya enzyme is also marketed in tablet form to remedy digestive problems. The black seeds are edible, and have a sharp, spicy taste. They are sometimes ground up and used as a substitute for black pepper.