maximum tolerated dose. The highest dose of a drug or other treatment that most people can safely withstand.

Maximum tolerated dose, is the maximum of any product that can be given to an animal, without killing it in a limited time. Many tests for carcinogenity use the MTD, half the MTD, a quarter of the MTD and no product, to do life time tests of animals to check for carcinogenity of a product. A real carcinogen developes excess cancers at the MTD and half that amount at half the MTD. etc... In fact at the MTD, the animal is continuously poisoned, that can result in a lot of excess cancers, caused by the poisoning, not the carcinogenity of the product. In such cases, lower doses give much lower cancer rates and at a certain level, no excess cancers are seen anymore. See the papers of Bruce N. Ames: "Too many rodent carcinogens" (not a popular scientific chat!).

maximum tolerated dose. Highest dose of a pesticide in chronic toxicity testing that is expected, on the basis of sub-chronic studies, to produce only limited toxicity when administered for the duration of the test period. (Duffus, 1993)

maximum tolerated dose. The highest dose that can be administered to animals for two years without causing more than 10% loss of weight greater than controls or other evidence of significant systemic toxicity; the aim is to test chemicals at the highest dose feasible in laboratory animals, generally rats and mice.

Maximum tolerable dose, Maximum tolerated dose

Maximum tolerated dose. The highest dose of an investigational drug that patients can tolerate without life-threatening or fatal side effects.

MAXIMUM TOLERATED DOSE. The highest dose that an organism can be exposed to without causing death or significant overt toxicity.

maximum tolerable dose. Highest amount of a substance that, when introduced into the body, does not kill test animals (denoted by LDo)

maximum tolerated dose. High dose used in chronic toxicity testing that is expected on the basis of an adequate subchronic study to produce limited toxicity when administered for the duration of the test period. It should not induce (a) overt toxicity, for example appreciable death of cells or organ dysfunction, or (b) toxic manifestations that are predicted materially to reduce the life span of the animals except as the result of neoplastic development or (c) 10% or greater retardation of body weight gain as compared with control animals. In some studies, toxicity that could interfere with a carcinogenic effect is specifically excluded from consideration

Maximum Tolerated Dose. Highest dosage of a drug, drug combination or other treatment modality that patients can safely tolerate. Usually determined by Phase I Trial.

Maximum Tolerated Dose. The highest dose of a chemical that does not shorten the organism's lifespan or cause severe damage to the organism.

Maximum tolerated dose, the dose that an animal species can tolerate for a major portion of its lifetime without significant impairment or toxic effect other than carcinogenicity.