County immediately to the west of London and adjacent to the capital.

Middlesex is one of the 39 historic counties of England and was the second smallest (after Rutland). When county councils were introduced in England in 1889 part of Middlesex was used to form the County of London and the remainder formed the administrative county of Middlesex.

Middlesex (also known as Middlesex—London—Lambton) was a federal electoral district represented in the Canadian House of Commons from 1968 to 1979. It was located in the province of Ontario. This riding was created in 1966 from parts of Lambton West, Lambton—Kent, Middlesex West and Middlesex East ridings.

Middlesex is a novel by Jeffrey Eugenides. It was published in 2002 and won the Pulitzer Prize for Fiction in 2003.

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