The difference between the estimated chronic dose and safe dose of a substance. The greater the difference, the greater the margin of safety.
The relationship between the doses of a drug required to produce undesired and desired effects.
the relationship between the desired therapeutic effects of a drug and it's adverse effects. (Also referred to as therapeutic index) This is an especially important concept because when drugs have a narrow margin of safety, there's little difference between a therapeutic does and a lethal dose.
Margin of safety (safety margin) is the difference between the intrinsic value of a stock (i.e. value based on stock valuation and what the company is actually worth) and the price that the market sets on a stock (i.e. stock price is a matter of market participants' opinions and is different from the intrinsic value).