Insignificance is a 1985 motion picture drama/comedy directed by Nicolas Roeg, produced by Jeremy Thomas and Alexander Stuart, and adapted by Terry Johnson from his play. The film is set in a hotel in 1954, and follows four characters who bear a striking resemblance to iconic figures of the era; Marilyn Monroe, Joseph Mc Carthy, Joe di Maggio and Albert Einstein. The film stars Theresa Russell, Tony Curtis, Michael Emil and Gary Busey.

Insignificance is an album by American musician Jim O'Rourke. It was released on Drag City in 2001. It is the third of three albums recorded by O'Rourke to be named after films by Nicolas Roeg, and features Jeff Tweedy and Glenn Kotche of Wilco (both of whom O'Rourke would later collaborate with as Loose Fur).

The condition or quality of being insignificant; lack of significance, sense, or meaning; as, the insignificance of words or phrases.

Lack of force or effect; unimportance; pettiness; inefficacy; as, the insignificance of human art.

Lack of claim to consideration or notice; lack of influence or standing; meanness.

the quality of having little or no significance