Conferring the ability on cells in culture to replicate indefinitely, usually by introduction of a gene into the cell's DNA.
The generation of cells that undergo an infinite number of division cycles. Immortalization of cells may be brought about by transfection with oncogenes, transfection with telomerase reverse transcriptase, induction by mutagens, or may be spontaneous.
Production of a cell line capable of an unlimited number of cell divisions. Can be the result of a chemical or viral transformation or of fusion with cells of a tumor line.
process by which cells in a culture can replicate indefinitely, usually through the introduction of a gene into the cell's DNA.
the ability of a genetically engineered cell line to reproduce indefinitely
the acquisition by an eukaryotic cell line of the ability to grow through an indefinite number of divisions in culture.
The attainment by a finite cell culture, whether by perturbation or intrinsically, of the attributes of a continuous cell line. An immortalized cell is not necessarily one which is neoplastically or malignantly transformed.