Grenoble (Arpitan: Grasanòbol) is a city and commune in south-east France, situated at the foot of the Alps, at the confluence of the Drac into the Isère River. Located in the Rhône-Alpes région, Grenoble is the préfecture (capital) of the département of Isère. Population of the city (commune) of Grenoble at the 1999 census was 153,317 inhabitants (157,900 inhabitants as of February 2004 estimates).