mutation which is a heritable thrombophilia (increased tendency of blood to clot, impaired natural anticoagulant or fibrinolytic pathways) present in 5 - 8% of Caucasian populations.
It is a specific mutation in the Factor V gene that is associated with an increased risk for venous thromboembolism.
Factor V is an important blood clotting protein. Factor V Leiden occurs when a specific mutation in the factor V gene results in a protein that is more resistant to being turned off, leading to an increased risk for forming blood clots. Factor V Leiden is the most common inherited hypercoagulable state.
The number one clotting disorder. It is inherited. Five percent of Caucasian Americans have it, 1.2 % of Afro-Americans. You can either be heterozygous (i.e. have one bad gene), homozygous ( i.e. have 2 bad genes) or normal (i.e. not have any bad genes). It is becoming more known because of the WWW and the FVL test now available. This test has only been available for around six years. Before that time, many folks died of clotting episodes not knowing why they had clotted.
A genetic disorder of blood coagulation (clotting) that carries an increased risk of venous thromboembolism -- the formation of clots in veins that may break loose and travel through the bloodstream to the lungs or brain. On the molecular level, factor V Leiden is characterized by a G to A substitution at nucleotide 1691 in the gene for factor V that causes a single amino acid replacement in the factor V protein. On the clotting level, factor V Leiden is inactivated about 10 times slower than normal factor V and persists longer in the circulation, resulting in increased generation of thrombin and a hypercoagulable state (thrombophilia). See the entire definition of Factor V Leiden
A hereditary blood coagulation disorder that can cause blood clots to deprive a developing baby of nutrients in a similar way to antiphospholipid syndrome.
an inherited mutation (change in a gene) in factor V which increases a person's risk for venous thrombosis.
Factor V Leiden (sometimes Factor VLeiden) is the name given to a variant of human factor V that causes a hypercoagulability disorder. In this disorder the Leiden variant of factor V, cannot be inactivated by activated protein C. Factor V Leiden is the most common hereditary hypercoagulability disorder amongst Eurasians.
