Definitions for "Endothelin"
The most powerful vasoconstrictor produced by the endothelium (endothelial cells lining blood vessels); also has growth-promoting effects
Group of peptide hormones produced by the vascular epithelium (walls of the blood vessels). When released it acts directly on the walls of blood vessels to cause vasoconstriction. It is the most potent vasoconstrictor known.
Group of hormone-like substances (messenger substances) that are formed in the endothelium; endothelin (ET) is the substance with the most powerful vasoconstricting effect in the body; ET causes the growth of inelastic connective tissue in the vessel wall and promotes inflammation. In pathological situations increased local production of ET seems to contribute to the development and severity of diseases like pulmonary arterial hypertension (PAH).