(previously "Effective Dose Equivalent") The International Commission for Radiological Protection's term (starting with ICRP Publication 60) for the sum of the products of (1) the weighting factors applicable to each body organ or tissue that is irradiated and (2) the mean equivalent dose in the tissue or organ.
Risk-related quantity used as indicator of overall patient dose. It is defined by the International Commission on Radiological Protection (ICRP) in Publication 60 (1991) as the sum of the weighted absorbed doses in all tissues and organs of the body:(mSv) where DT is the absorbed dose (mGy) in tissue T due to radiation R, wR is the weighting factor for radiation R and wT is the weighting factor for tissue T. For x-rays, wR is equal to unity.
sum of dose equivalents imparted to the various tissues and organs of an individual, weighted by a factor specific to each organ or tissue. Expressed in sieverts (Sv)
the dose of a certain substance, which cause a particular effect in 50% of the people or the lab animals, who have tried it
a dosimetric quantity useful for comparing the overall health affects of irradiation of the whole body. It takes into account the absorbed doses received by various organs and tissues and weighs them according to present knowledge of the sensitivity of each organ to radiation. It also accounts for the type of radiation and the potential for each type to inflict biologic damage. The effective dose is used, for example, to compare the overall health detriments of different radionuclides in a given mix. The unit of effective dose is the sievert (Sv); 1 Sv = 1 J/kg. For more information, see " Primer on Radiation Measurement" at the end of this document.
The sum over specified organs or tissues of the equivalent dose in each tissue modified by the tissue weighting factor, as defined in ICRP (1991a). Supersedes effective dose equivalent.
The ED50 is the effective dose for 50 percent of tested subjects.
The dose of an investigational agent that produces the outcome considered "effective," as defined in the study protocol. This could mean a cure of the disease in question or simply the mitigation of symptoms.
The radiation dose allowing for the fact that 1) some types of radiation are more damaging than others, and 2) some parts of the body are more sensitive to radiation than others. It is defined as the sum over specified tissues of the products of the equivalent dose in a tissue (T) and the weighting factor for that tissue (WT).
Dose of a substance that causes a defined magnitude of response in a given system: ED50 is the median dose that causes 50 % of maximal response BT dose RT lethal dose
The quantity obtained by multiplying the equivalent dose to various tissues and organs by a weighting factor appropriate to each and summing the products. Unit sievert, symbol Sv. Frequently abbreviated to dose.
The dose corresponding to a 10% increase in an adverse effect, relative to the control response.
An effective dose is the smallest dose of a substance required to produce a measurable effect on a living organism.
