naturally occurring substances that regulate growth and maturation of white blood cells. There are several commercially available CSFs, including Neupogen, Neulasta and Leukine.
Naturally occurring glycoproteins that regulate the proliferation, differentiation and maturation of hematopoietic growth factors, belong to a class of soluble immunt system proteins known as cytokines.
Protein that stimulates the development and growth of blood cells; sometimes called growth factor. Granulocyte colony-stimulating factor is a CSF that is used to mobilize stem cells from the bone marrow into the bloodstream prior to apheresis.
An injectible substance used to stimulate the bone marrow to produce more cells.
A man-made protein very similar to naturally produced proteins in the body that predominantly signal the production of white blood cells.
a treatment agent used to stimulate the production of certain blood cells in the bone marrow. Agents include granulocyte colony-stimulating factor ( G-CSF) and granulocyte-macrophage colony-stimulating factor ( GM-CSF)
a cytokine responsible for regulating the production of white blood cells. Types include granulocyte colony-stimulating factor (G-CSF) and granulocyte macrophage colony-stimulating factor (GM-CSF), which are used to relieve neutropenia.
A compound used to stimulate the bone marrow to produce more cells.
Colony-stimulating factors (CSFs) are secreted glycoproteins which bind to receptor proteins on the surfaces of hemopoietic stem cells and thereby activate intracellular signaling pathways which can cause the cells to proliferate and differentiate into a specific kind of blood cell (usually white blood cells, for red blood cell formation see erythropoietin). The name "colony-stimulating factors" comes from the method by which they were discovered. Hemopoietic stem cells were cultured (see cell culture) on a so-called semi solid matrix which prevents cells from moving around, so that if a single cell starts proliferating, all of the cells derived from it will remain clustered around the spot in the matrix where the first cell was originally located, and these are referred to as "colonies."
