Caleb, played by Nathan Fillion, is a fictional character in the television series Buffy the Vampire Slayer created by Joss Whedon.

Caleb is a fictional character in comic book W.I.T.C.H. and the animated series of the same name.

Caleb is the protagonist of the computer games Blood and Blood II: The Chosen. He is created by Monolith Productions, which is also the creator behind the series. Stephan Weyte did the voice of Caleb for both games.

One of the twelve spies Joshua sent into Canaan; of the generation which left Egypt in the Exodus, only he and Joshua were allowed to enter Canaan.