(Area Under the Curve) The total exposure of a compound during its prescribed dosing interval. The AUC is calculated by obtaining serial drug levels during an entire dosing period, and then determining the total serum concentration of the drug throughout that period. While AUC does assess total drug exposure with great accuracy, its use in clinical practice is limited by the fact that it requires multiple samples over a given dosing interval.
Area Under the Curve Used to summarise the information from a series of measurements on one subject. Consecutive data points are joined together by a straight line and the AUC calculated normally using the trapezoidal rule.
Area under the curve (statistics; pharmacokinetics)
Area under the curve, a measure of total exposure to a drug over a 24-hour period.