pioglitazone, one of the thiazolidinedione group of drugs. FDA approved to help with treatment of diabetes, it is also has anti-inflammatory effects by blocking the cyto- kine nuclear receptor activity and thereby lowering elevated levels of leptin, MMP9, PAI-1. It may have benefit in treatment of multiple chemical sensitivity (MCS) if the MCS is diagnosed early. Actos is one of the most useful of the medications of the Biotoxin Pathway